Does Botox work for all types of wrinkles? The short answer is no. Botox works great for expression lines in the crow’s feet area, the forehead, and the area between the eyebrows. These are shallow wrinkles that appear when you smile, frown or show annoyance. It does not have the same effect on deep skin wrinkles or permanent folds. The milder the wrinkle, the more likely that Botox will be able to eliminate it. When a wrinkle is very deep Botox will have to be combined with dermal fillers or a surgical procedure to have a significant effect on its appearance.