Does Botox work to treat bags under the eyes? The short answer is no. The reason it does not work is that Botox is used to relax the muscles of facial expression, not to remove fatty tissue. By relaxing the muscles, Botox may reduce fine lines and wrinkles, such as crow’s feet and frown lines, but it cannot eliminate bags. In order to get rid of bags, the fatty tissue must be excised surgically. This is why lower eyelid blepharoplasty is necessary to address the issue.