At what age can I start applying Botox?Filler injections are not painful, if done the right way. A mindful surgeon or dermatologist will make sure that the patient feels comfortable during the entire procedure. The best way to achieve good results with little discomfort is to block the nerves that are responsible for sending pain signals to the brain. The plastic surgeon will perform “nerve blocks” in the area where he wants to inject the filler; this will guarantee a painless application and a happy patient.